Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786463 | 1.00 | GAA (0.57) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL19850671 | 0.92 | SMN1; SMN2 (0.64) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL1169368 | 0.85 | SMN1; SMN2 (0.56) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL9803175 | 0.80 | SMN1; SMN2 (0.53) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL14895396 | 0.80 | SMN1; SMN2 (0.53) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL16032593 | 0.76 | SMN1; SMN2 (0.50) | GAASMN1; SMN2POLBLMNAALDH1A1 | |
| SCHEMBL3904169 | 0.75 | SMN1; SMN2 (0.90) | GAASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL9802440 | 0.74 | GAA (0.71) | GAASMN1; SMN2POLBLMNAALDH1A1 | |
| SCHEMBL29791881 | 0.72 | GAA (0.46) | GAASMN1; SMN2POLBKDM4ELMNA | |
| SCHEMBL29791834 | 0.72 | GAA (0.46) | GAASMN1; SMN2POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026798-A1 | SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |