Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332838 | 1.00 | RPS6KA5 (0.52) | RPS6KA5ALDH1A1FGFR1ATMMAPK1 | |
| SCHEMBL889831 | 0.80 | MAPK1 (0.61) | ALDH1A1ATMMAPK1HTTKDM4E | |
| SCHEMBL540767 | 0.80 | MAPK1 (0.67) | RPS6KA5ALDH1A1ATMMAPK1HTT | |
| SCHEMBL16054504 | 0.80 | RPS6KA5 (0.52) | RPS6KA5ALDH1A1FGFR1ATMMAPK1 | |
| SCHEMBL27949768 | 0.79 | MAPK1 (0.59) | ALDH1A1ATMMAPK1HTTKDM4E | |
| SCHEMBL10247453 | 0.79 | ATM (0.65) | RPS6KA5ALDH1A1FGFR1ATMHTT | |
| SCHEMBL14420337 | 0.79 | GSR (0.52) | ALDH1A1MAPK1HTTKDM4ENPC1 | |
| SCHEMBL24477016 | 0.76 | RPS6KA5 (0.49) | RPS6KA5ALDH1A1FGFR1ATMMAPK1 | |
| SCHEMBL11901799 | 0.76 | RPS6KA5 (0.49) | RPS6KA5ALDH1A1FGFR1ATMMAPK1 | |
| SCHEMBL16035164 | 0.76 | RPS6KA5 (0.49) | RPS6KA5ALDH1A1FGFR1ATMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-09-03 | — | — | US | disclosed |
| EP-3495362-A1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shandong University (CN) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018023851-A1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 山东大学 | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SLC29A1, SLC28A1, SLC5A1 | RPS6KA5 4353/4885ALDH1A1 473/4885FGFR1 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.