Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | PRNP | P04156 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851096 | 0.88 | TSHR (0.56) | CYP2C9CYP3A4ALDH1A1PRNPNPSR1 | |
| SCHEMBL21094240 | 0.86 | ALDH1A1 (0.43) | CYP2C9SLC22A12CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL23954456 | 0.85 | ALDH1A1 (0.47) | CYP2C9SLC22A12CYP2C19PTGS2CYP3A4 | |
| SCHEMBL19851020 | 0.85 | SLC22A12 (0.74) | CYP2C9SLC22A12CYP2C19PTGS2CYP3A4 | |
| SCHEMBL19851109 | 0.84 | ALDH1A1 (0.40) | CYP2C9SLC22A12CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL19851161 | 0.83 | ALDH1A1 (0.39) | CYP2C9SLC22A12CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL19851098 | 0.80 | SLC22A12 (0.54) | CYP2C9SLC22A12CYP3A4ALDH1A1MAPK1 | |
| SCHEMBL19851103 | 0.80 | ALDH1A1 (0.53) | CYP2C9CYP3A4ALDH1A1MAPK1KDM4E | |
| SCHEMBL21093621 | 0.77 | ALDH1A1 (0.49) | CYP2C9CYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL19851108 | 0.77 | ALDH1A1 (0.40) | CYP2C9SLC22A12CYP3A4ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495362-B1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | UNIV SHANDONG (CN) | 2021-10-27 | — | — | EP | disclosed |
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-09-03 | — | — | US | disclosed |
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-07-25 | — | — | US | disclosed |
| EP-3495362-A1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shandong University (CN) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018023851-A1 | IMIDAZOPYRIDINE THIOGLYCOLIC ACID DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 山东大学 | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SLC29A1, SLC28A1, SLC5A1 | CYP2C9 292/4885SLC22A12 118/4885CYP2C19 1044/4885 |
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SLC29A1, SLC28A1, SLC5A1 | CYP2C9 254/4885SLC22A12 163/4885CYP2C19 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.