Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.30 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27094531 | 0.85 | HTR2C (0.37) | HTR2AHTR2CHTR2BKMT2AMEN1 | |
| SCHEMBL27094507 | 0.85 | HTR2C (0.37) | HTR2AHTR2CHTR2BKMT2AMEN1 | |
| SCHEMBL11886343 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYP11B1CYP11B2 | |
| SCHEMBL19251265 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYP11B1CYP11B2 | |
| SCHEMBL19250881 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYP11B1CYP11B2 | |
| SCHEMBL19250878 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYP11B1CYP11B2 | |
| SCHEMBL27094595 | 0.75 | P2RX7 (0.41) | HTR2AHTR2CHTR2BP2RX7OPRL1 | |
| SCHEMBL27094563 | 0.75 | P2RX7 (0.41) | HTR2AHTR2CHTR2BP2RX7OPRL1 | |
| SCHEMBL21133924 | 0.75 | HTR2A (0.39) | HTR2AHTR2CHTR2BKMT2AMEN1 | |
| SCHEMBL27094569 | 0.75 | P2RX7 (0.41) | HTR2AHTR2CHTR2BP2RX7OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037570-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037570-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | HTR2A 694/4885HTR2C 942/4885HTR2B 1007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.