Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853462 | 0.81 | MEN1 (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838967 | 0.81 | OPRM1 (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838997 | 0.81 | MEN1 (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838968 | 0.81 | OPRM1 (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19853460 | 0.77 | OPRM1 (0.41) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838987 | 0.74 | TSHR (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838985 | 0.74 | TSHR (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19853389 | 0.74 | TSHR (0.38) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL23430085 | 0.72 | MEN1 (0.34) | MEN1KMT2AMMP1MMP2MMP3 | |
| SCHEMBL19838999 | 0.72 | MEN1 (0.34) | MEN1KMT2AMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026792-A1 | SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |