Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853738 | 0.88 | CTSK (0.36) | — | |
| SCHEMBL21034802 | 0.88 | CTSK (0.36) | — | |
| SCHEMBL19854895 | 0.86 | EP300 (0.33) | — | |
| SCHEMBL24634129 | 0.81 | EP300 (0.36) | — | |
| SCHEMBL19853723 | 0.77 | JAK2 (0.37) | EPHX1 | |
| SCHEMBL19854892 | 0.76 | JAK2 (0.36) | GRIN2BGRIN2CEPHX1 | |
| SCHEMBL21034294 | 0.76 | EP300 (0.37) | LMNA | |
| SCHEMBL19839392 | 0.76 | EP300 (0.37) | LMNA | |
| SCHEMBL19853784 | 0.74 | EP300 (0.33) | LMNA | |
| SCHEMBL19854870 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |