Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | ACACA | Q13085 | 2/20 | 0.31 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24230513 | 0.82 | OTUD7B (0.38) | BACE1DPP4PDE4AACACBACACA | |
| SCHEMBL19839388 | 0.77 | CRBN (0.36) | — | |
| SCHEMBL10484796 | 0.72 | DPP4 (0.37) | BACE1DPP4SLC6A4SLC6A3 | |
| SCHEMBL19853700 | 0.72 | CRBN (0.31) | — | |
| SCHEMBL19839331 | 0.72 | CRBN (0.31) | — | |
| SCHEMBL19853761 | 0.72 | — | — | |
| SCHEMBL7814916 | 0.71 | — | — | |
| SCHEMBL8224882 | 0.71 | — | — | |
| SCHEMBL3540442 | 0.69 | BACE1 (0.44) | BACE1ACACBACACA | |
| SCHEMBL7820372 | 0.69 | CRBN (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |