SCHEMBL19856414

SCHEMBL19856414

O=C=Nc1ccc(C2CC2)c2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.40
HTR6 P50406 1/20 0.36
MTNR1A P48039 1/20 0.34
SLC6A4 P31645 2/20 0.33
CYP1A2 P05177 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
ABCB11 O95342 1/20 0.33
NR3C1 P04150 1/20 0.33
ADRA2A P08913 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
ALOX15 P16050 1/20 0.33
ADRA2C P18825 1/20 0.33
MAOA P21397 1/20 0.33
DRD1 P21728 1/20 0.33
HTR2B P41595 1/20 0.33
CCR2 P41597 1/20 0.33
HSD17B10 Q99714 1/20 0.33
DRD2 P14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12104293 0.83 SLC6A4 (0.33) CYP3A4HTR6SLC6A4CYP1A2ALDH1A1
SCHEMBL248662 0.83 SLC6A4 (0.53) CYP3A4HTR6SLC6A4CYP1A2ALDH1A1
SCHEMBL27066 0.81 CYP3A4 (0.50) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD
SCHEMBL29405309 0.81 CYP3A4 (0.50) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD
SCHEMBL4749769 0.80 HTR6 (0.39) CYP3A4HTR6MTNR1ASLC6A4CYP1A2
SCHEMBL19611023 0.78 CYP3A4 (0.45) CYP3A4ALDH1A1HPGDTDP1HSD17B10
SCHEMBL22210 0.77 CYP3A4 (0.62) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD
SCHEMBL29370250 0.77 CYP3A4 (0.62) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD
SCHEMBL11382980 0.75 CYP3A4 (0.45) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD
SCHEMBL28189098 0.75 CYP3A4 (0.45) CYP3A4SLC6A4CYP1A2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3281941-A1 PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID Zentiva K.S. (CZ) 2018-02-14 EP disclosed