Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 18/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 17/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 17/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | PDE8A | O60658 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | PDE9A | O76083 | 1/20 | 0.52 |
| ▸ | PDE8B | O95263 | 1/20 | 0.52 |
| ▸ | PDE6A | P16499 | 1/20 | 0.52 |
| ▸ | PDE6G | P18545 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE6B | P35913 | 1/20 | 0.52 |
| ▸ | PDE6C | P51160 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856624 | 0.91 | CHRM3 (0.80) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL1924497 | 0.91 | CHRM2 (0.80) | CHRM3CHRM2CHRM1TSHRRXFP1 | |
| SCHEMBL15761782 | 0.90 | CHRM3 (0.64) | CHRM3CHRM2CHRM1TSHRRXFP1 | |
| SCHEMBL19856615 | 0.90 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856565 | 0.89 | CHRM3 (0.85) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856597 | 0.89 | CHRM3 (0.67) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856652 | 0.87 | CHRM3 (0.65) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856642 | 0.87 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856590 | 0.86 | CHRM3 (0.67) | CHRM3CHRM2CHRM1CHRM5CHRM4 | |
| SCHEMBL19856548 | 0.86 | CHRM3 (0.64) | CHRM3CHRM2CHRM1CHRM5CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928880-B1 | PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS AND MUSCARINIC RECEPTOR ANTAGONISTS | CHIESI FARM SPA (IT) | 2018-02-14 | — | — | EP | claimed |