Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.76 |
| ▸ | TACR2 | P21452 | 2/20 | 0.67 |
| ▸ | TACR3 | P29371 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900880 | 1.00 | TRPV4 (0.76) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL14480526 | 0.96 | TRPV4 (0.76) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6899517 | 0.94 | TRPV4 (0.76) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL19857015 | 0.94 | TRPV4 (0.78) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6898884 | 0.94 | TRPV4 (0.78) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6897359 | 0.94 | TRPV4 (0.70) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6897363 | 0.94 | TRPV4 (0.77) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL19857007 | 0.94 | TRPV4 (0.77) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL19857013 | 0.91 | TRPV4 (0.76) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL14480313 | 0.91 | TRPV4 (0.76) | TRPV4TACR2TACR3KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |