Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 20/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | TACR2 | P21452 | 2/20 | 0.70 |
| ▸ | TACR3 | P29371 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.70 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900877 | 1.00 | TRPV4 (0.81) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL19857009 | 0.99 | TRPV4 (0.82) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL6898942 | 0.99 | TRPV4 (0.82) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL6899818 | 0.99 | TRPV4 (0.82) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL14553198 | 0.99 | TRPV4 (0.82) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL14480275 | 0.99 | TRPV4 (0.82) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL14553184 | 0.95 | TRPV4 (0.74) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL14480406 | 0.95 | TRPV4 (0.74) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL6899967 | 0.95 | TRPV4 (0.83) | TRPV4NR1I2TACR2TACR3KCNH2 | |
| SCHEMBL14553177 | 0.95 | TRPV4 (0.83) | TRPV4NR1I2TACR2TACR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |