Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 1.00 |
| ▸ | CD63 | P08962 | 4/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 2/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | ROS1 | P08922 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.64 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12006450 | 0.87 | SYK (0.77) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL29664257 | 0.86 | SYK (1.00) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2476093 | 0.86 | SYK (1.00) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2482275 | 0.85 | AURKA (0.79) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL24864097 | 0.83 | SYK (0.79) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL19981186 | 0.83 | SYK (0.71) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2481740 | 0.83 | SYK (0.80) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2478698 | 0.82 | SYK (0.70) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2482299 | 0.82 | AURKA (0.73) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL23911850 | 0.82 | AURKA (0.81) | SYKCD63AURKAJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342773-B9 | SYK INHIBITORS | KRONOS BIO INC (US) | 2021-06-09 | — | — | EP | disclosed |
| EP-3342773-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2020-11-11 | — | — | EP | disclosed |
| EP-3342773-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-3087075-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2018-02-14 | — | — | EP | disclosed |