Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.71 |
| ▸ | CD63 | P08962 | 2/20 | 0.71 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | ROS1 | P08922 | 1/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | BTK | Q06187 | 1/20 | 0.65 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.65 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27306130 | 0.92 | SYK (0.60) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL18455117 | 0.91 | SYK (0.60) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL18455114 | 0.89 | SYK (0.68) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL18455219 | 0.87 | SYK (0.54) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL2476114 | 0.86 | SYK (0.70) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL2482275 | 0.86 | AURKA (0.79) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL2479430 | 0.85 | SYK (0.71) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL24864097 | 0.84 | SYK (0.79) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL2477684 | 0.83 | SYK (0.66) | SYKCD63JAK2NTRK1ROS1 | |
| SCHEMBL18455121 | 0.83 | AURKA (0.51) | SYKCD63JAK2NTRK1ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3076976-B1 | METHODS FOR TREATING CANCERS | GILEAD SCIENCES INC (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3027618-B1 | POLYMORPH OF SYK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019040298-A1 | POLYMORPHS OF SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2018053190-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |
| WO-2018053189-A2 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |