Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863583 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19857443 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19857309 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19863584 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19863585 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL29593581 | 1.00 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19863586 | 0.93 | HTT (0.40) | HTTMERTK | |
| SCHEMBL20801453 | 0.93 | HTT (0.40) | HTTMERTK | |
| SCHEMBL24669666 | 0.84 | HTT (0.42) | HTTMERTK | |
| SCHEMBL28294289 | 0.81 | HTT (0.42) | HTTMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233188-B2 | CDK2/4/6 inhibitors | PFIZER INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180044344-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044344-A1 | CDK2/4/6 Inhibitors | CDK2, CDK6, CDK20 | HTT 3428/4885MERTK 3203/4885 |
| US-10233188-B2 | CDK2/4/6 inhibitors | CDK2, CDK6, CDK20 | HTT 3428/4885MERTK 3203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.