Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 3/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669666 | 0.88 | HTT (0.42) | HTTLATS1LATS2MERTKJAK2 | |
| SCHEMBL20801453 | 0.87 | HTT (0.40) | HTTLATS1LATS2MERTKJAK2 | |
| SCHEMBL19863586 | 0.87 | HTT (0.40) | HTTLATS1LATS2MERTKJAK2 | |
| SCHEMBL22860693 | 0.84 | MERTK (0.46) | HTTMERTKMEN1KMT2AJAK2 | |
| SCHEMBL2622288 | 0.82 | GABBR2 (0.47) | HTTMERTKMEN1KMT2AJAK2 | |
| SCHEMBL19863584 | 0.81 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19857443 | 0.81 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19863583 | 0.81 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19857513 | 0.81 | HTT (0.41) | HTTMERTK | |
| SCHEMBL19863585 | 0.81 | HTT (0.41) | HTTMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803968-A | Pyridopyrimidinone CDK2/4/6 inhibitor | 辉瑞公司 | 2019-05-24 | — | — | CN | disclosed |