Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.57 |
| ▸ | CHUK | O15111 | 3/20 | 0.57 |
| ▸ | AKT1 | P31749 | 3/20 | 0.57 |
| ▸ | AKT2 | P31751 | 3/20 | 0.57 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.57 |
| ▸ | MAP2 | P11137 | 5/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863777 | 0.89 | CSF1R (0.60) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL6059495 | 0.87 | MAP2 (0.74) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL30043560 | 0.87 | MAP2 (0.74) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL19857834 | 0.87 | MAP2 (0.53) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL23511140 | 0.85 | MAP2 (0.67) | MAP2CSF1RPADI4ATMRAD51 | |
| SCHEMBL19857711 | 0.85 | MAP2 (0.67) | MAP2CSF1RPADI4ATMKDM4E | |
| SCHEMBL30043961 | 0.85 | MAP2 (0.67) | MAP2CSF1RPADI4ATMRAD51 | |
| SCHEMBL17457314 | 0.85 | CSF1R (0.57) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL19857829 | 0.84 | CSF1R (0.55) | IKBKBCHUKAKT1AKT2AKT3 | |
| SCHEMBL22899476 | 0.84 | PADI4 (0.57) | IKBKBCHUKAKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-03 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | EIF4E, EIF4A1, EIF4A2 | IKBKB 1115/4885CHUK 724/4885AKT1 1418/4885 |
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | EIF4E, EIF4A1, EIF4A2 | IKBKB 1115/4885CHUK 724/4885AKT1 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.