Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863786 | 0.85 | CCR9 (0.54) | CCR9THRBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19857760 | 0.79 | CCR9 (0.49) | CCR9MAPTMAPK1LMNA | |
| SCHEMBL2880280 | 0.79 | TP53 (0.60) | CCR9MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28301 | 0.78 | CCR9 (0.74) | CCR9MAPTALDH1A1KMT2ATP53 | |
| SCHEMBL3833768 | 0.76 | PPARA (0.63) | MAPTSMN1; SMN2MEN1MAPK1KMT2A | |
| SCHEMBL19857771 | 0.76 | TOP2A (0.42) | CCR9THRBALDH1A1MEN1POLB | |
| SCHEMBL19857833 | 0.75 | MAPT (0.53) | THRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL344126 | 0.74 | CCR9 (0.78) | CCR9MAPTKMT2ATP53LMNA | |
| SCHEMBL6757678 | 0.74 | IGF2BP2 (0.50) | THRBMAPTALDH1A1POLBKMT2A | |
| SCHEMBL11063162 | 0.73 | POLB (0.50) | CCR9MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-03 | — | — | US | disclosed |
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | Sanford Burnham Prebys Medical Discovery Institute | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044324-A1 | Quinolinones as Inhibitors of Translation Initiation Complex | EIF4E, EIF4A1, EIF4A2 | CCR9 4805/4885THRB 3819/4885MAPT 1569/4885 |
| US-10577349-B2 | Quinolinones as inhibitors of translation initiation complex | EIF4E, EIF4A1, EIF4A2 | CCR9 4805/4885THRB 3819/4885MAPT 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.