Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985581 | 0.83 | MEN1 (0.67) | RAB9ANPC1MEN1KMT2ATDP1 | |
| SCHEMBL19860113 | 0.81 | NPC1 (0.76) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12058758 | 0.81 | RAB9A (0.61) | RAB9ANPC1MEN1KMT2ATDP1 | |
| SCHEMBL12042436 | 0.80 | RAB9A (0.60) | RAB9ANPC1MEN1KMT2ATDP1 | |
| SCHEMBL3224360 | 0.79 | RAB9A (0.71) | RAB9ANPC1MEN1KMT2ATDP1 | |
| SCHEMBL21903679 | 0.78 | MEN1 (0.64) | RAB9ANPC1MEN1KMT2ATDP1 | |
| SCHEMBL24726481 | 0.77 | SIRT2 (0.61) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10978860 | 0.77 | RAB9A (0.86) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10094388 | 0.77 | SIRT2 (0.63) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23809485 | 0.76 | NPC1 (0.55) | RAB9ANPC1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |