Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986940 | 0.93 | TRPV1 (0.62) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5934320 | 0.88 | TRPV1 (0.58) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6308329 | 0.88 | RAB9A (0.55) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5783405 | 0.88 | TRPV1 (0.76) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14985573 | 0.87 | TRPV1 (0.79) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5781407 | 0.85 | TRPV1 (0.76) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30369793 | 0.85 | RAB9A (0.81) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5787140 | 0.84 | RAB9A (0.74) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5781677 | 0.84 | TRPV1 (1.00) | TRPV1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13763263 | 0.83 | TRPV1 (0.80) | TRPV1LMNARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |