Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983811 | 0.90 | MAPT (0.40) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1985549 | 0.90 | MAPT (0.40) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1986031 | 0.88 | PDE4D (0.41) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1983557 | 0.87 | MAPT (0.38) | MAPTNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL1986009 | 0.83 | TP53 (0.51) | MAPTCCNA2CDK2CCNA1L3MBTL1 | |
| SCHEMBL1984758 | 0.83 | MAPT (0.40) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1985610 | 0.82 | MAPT (0.39) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1985425 | 0.81 | MALT1 (0.40) | MAPTNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1986855 | 0.79 | CNR1 (0.41) | MAPTSMN1; SMN2TP53KMT2ALMNA | |
| SCHEMBL1987138 | 0.78 | TP53 (0.39) | MAPTNPC1RAB9ASMN1; SMN2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1602656-B1 | PYRAZOLE DERIVATIVES HAVING AFFINITY FOR CB1 AND/OR CB2 RECEPTORS | NEUROSCIENZE PHARMANESS S C A R L (IT) | 2011-06-29 | — | — | EP | claimed |