Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152404 | 0.88 | PDK2 (0.39) | PDK2THRBTDP1MEN1KMT2A | |
| SCHEMBL19669965 | 0.83 | PDK2 (0.36) | PDK2THRBTDP1MEN1KMT2A | |
| SCHEMBL22435806 | 0.82 | PDK2 (0.35) | PDK2THRBTDP1MEN1KMT2A | |
| SCHEMBL21564256 | 0.81 | PDK2 (0.35) | PDK2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL21867770 | 0.80 | PDK2 (0.34) | PDK2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL21534174 | 0.78 | PDK2 (0.39) | PDK2THRBTDP1MEN1KMT2A | |
| SCHEMBL20169416 | 0.77 | PDK2 (0.39) | PDK2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL24406310 | 0.77 | PDK2 (0.42) | PDK2ESR1ESR2 | |
| SCHEMBL21922630 | 0.77 | PDK2 (0.36) | PDK2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL20697977 | 0.77 | MEN1 (0.37) | PDK2THRBTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9893299-B2 | Heterocyclic compounds | MERCK PATENT GMBH (DE) | 2018-02-13 | — | — | US | disclosed |