Sugi Predict

Sugi Predict / Compounds / SCHEMBL1986018

SCHEMBL1986018

SCHEMBL1986018

COc1ccc2nc(-c3ccc(/N=N/c4ccc(O)cc4OC(F)(F)F)c(OC)c3)sc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SULT1A1 P50225 1/20 0.55
▸ APP P05067 7/20 0.50
▸ GLA P06280 2/20 0.46
▸ GAA P10253 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ PPARG P37231 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ NCOA2 Q15596 1/20 0.43
▸ NCOA1 Q15788 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ TUBB4A P04350 1/20 0.43
▸ TUBB P07437 1/20 0.43
▸ TUBA3C P0DPH7 1/20 0.43
▸ TUBA1B P68363 1/20 0.43
▸ TUBA4A P68366 1/20 0.43
▸ TUBB4B P68371 1/20 0.43
▸ TUBB3 Q13509 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1986022 1.00 SULT1A1 (0.55) SULT1A1APPGLAGAAKDM4E
SCHEMBL13391709 0.94 SULT1A1 (0.54) SULT1A1APPGLAGAAKDM4E
SCHEMBL16623353 0.90 SULT1A1 (0.57) SULT1A1APPGLAGAAKDM4E
SCHEMBL2197676 0.89 SULT1A1 (0.55) SULT1A1APPGLAGAAKDM4E
SCHEMBL2197668 0.89 SULT1A1 (0.55) SULT1A1APPGLAGAAKDM4E
SCHEMBL1983807 0.84 APP (0.50) SULT1A1APPKDM4EALDH1A1MAPT
SCHEMBL1983812 0.84 APP (0.50) SULT1A1APPKDM4EALDH1A1MAPT
SCHEMBL1984259 0.78 SULT1A1 (0.59) SULT1A1APPGLAGAA
SCHEMBL1984255 0.78 SULT1A1 (0.59) SULT1A1APPGLAGAA
SCHEMBL12422468 0.77 SULT1A1 (0.52) SULT1A1APPGLAGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2338059-B1 Ligands for aggregated tau molecules WISTA LAB LTD (SG) 2015-04-08 — — EP disclosed
EP-2338059-B1 Ligands for aggregated tau molecules WISTA LAB LTD (SG) 2015-04-08 — — EP disclosed
US-8895313-B2 Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-11-25 — — US disclosed
US-8895313-B2 Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-11-25 — — US disclosed
CN-102224423-A Ligands for aggregated tau molecules WISTA LAB LTD 2011-10-19 — — CN disclosed
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. 2011-07-14 — — US disclosed
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. 2011-07-14 — — US disclosed
EP-2338059-A1 LIGANDS FOR AGGREGATED TAU MOLECULES Wista Laboratories Ltd. (SG) 2011-06-29 — — EP disclosed
WO-2010034982-A1 LIGANDS FOR AGGREGATED TAU MOLECULES WISTA LABORATORIES LTD. (SG) 2010-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171739-A1 LIGANDS FOR AGGREGATED TAU MOLECULES MAPT, PRNP, MAP4 SULT1A1 2925/4885APP 17/4885GLA 1532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.