Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | BAD | Q92934 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540826 | 0.99 | MAPT (0.52) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL17997088 | 0.99 | MAPT (0.52) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL2852780 | 0.84 | ALDH1A1 (0.42) | MAPTNPC1ALDH1A1MCL1PTPN1 | |
| SCHEMBL16541083 | 0.83 | MCL1 (0.46) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL4672754 | 0.83 | MCL1 (0.65) | NPC1KMT2ATSHRMCL1PTPN1 | |
| SCHEMBL16540839 | 0.82 | PLK1 (0.52) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL16540523 | 0.82 | KDM4E (0.51) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL19861123 | 0.82 | MAPT (0.46) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL16540650 | 0.82 | MAPT (0.57) | MAPTNPC1KMT2AALDH1A1TSHR | |
| SCHEMBL16547892 | 0.82 | MAPT (0.57) | MAPTNPC1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890132-B2 | Process for the preparation of anti-inflammatory aroylbenzofuran compounds | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-02-13 | — | — | US | disclosed |