Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992956 | 0.88 | CAPN1 (0.50) | CAPN1 | |
| SCHEMBL1994167 | 0.87 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL1992804 | 0.86 | CAPN1 (0.55) | CAPN1 | |
| SCHEMBL1988965 | 0.85 | CAPN1 (0.72) | CAPN1 | |
| SCHEMBL1992966 | 0.85 | CAPN1 (0.72) | CAPN1 | |
| SCHEMBL1988967 | 0.85 | CAPN1 (0.72) | CAPN1 | |
| SCHEMBL9900875 | 0.85 | CAPN1 (0.61) | CAPN1 | |
| SCHEMBL1990682 | 0.85 | CAPN1 (0.73) | CAPN1 | |
| SCHEMBL1996199 | 0.84 | CAPN1 (0.48) | CAPN1 | |
| SCHEMBL1990242 | 0.83 | CAPN1 (0.66) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-06-26 | — | — | US | disclosed |
| US-8598211-B2 | Carboxamide compounds and their use as calpain inhibitors IV | ABBVIE INC. (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2516415-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | Abbott GmbH & Co. KG (DE) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076812-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPNS1, CAPN1 | CAPN1 3/4885 |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPN1, CAPN9 | CAPN1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.