CAPN9 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8219586	0.81	3/20
SCHEMBL4777829	0.79	3/20
SCHEMBL7297722	0.77	3/20
SCHEMBL7306078	0.77	3/20
SCHEMBL7298531	0.73	3/20
SCHEMBL7305468	0.73	3/20
Aloxistatin (SCHEMBL254426)	0.72	3/20
Aloxistatin (SCHEMBL483320)	0.72	3/20
SCHEMBL7300861	0.64	3/20
Aloxistatin (SCHEMBL9314220)	0.64	3/20
SCHEMBL7364463	0.63	3/20
SCHEMBL1804811	0.60	3/20
Formic Acid (SCHEMBL7305237)	0.57	3/20
SCHEMBL4777823	0.56	3/20
SCHEMBL7302942	0.56	3/20
SCHEMBL7364469	0.55	3/20
SCHEMBL7300867	0.55	3/20
Formic Acid (SCHEMBL7299223)	0.54	3/20
SCHEMBL7404688	0.54	3/20
SCHEMBL7359662	0.53	3/20

Clinical trials — most relevant to CAPN9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy	PHASE2/PHASE3	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Evaluation of the Safety and Efficacy of BBM-D101 to Treat Patients with Duchenne Muscular Dystrophy	EARLY_PHASE1	RECRUITING
Clinical and Biochemical Features for the Identification of Dominant Calpainopathies	nan	UNKNOWN
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease	nan	COMPLETED
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
LGMD R1 Natural History Study	nan	ACTIVE_NOT_RECRUITING
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Congenital Muscle Disease Study of Patient and Family Reported Medical Information	nan	RECRUITING
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis	nan	UNKNOWN
CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD	nan	ENROLLING_BY_INVITATION
Evolution of the Functional and Muscular State of Patients With Muscular Dystrophy 2A Belts	nan	ACTIVE_NOT_RECRUITING
Genetics of Familial and Sporadic ALS	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China	nan	ENROLLING_BY_INVITATION
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program	nan	COMPLETED
Blood-based Biomarkers for the Prognosis of Sports Related Concussion	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests	nan	UNKNOWN
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures	nan	RECRUITING
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases	nan	COMPLETED
Collection of Blood Samples for DNA in Motor Neuron Disease	nan	COMPLETED
S100A8 in Serum and Urine as a New Biomarker in Lupus Nephritis	nan	COMPLETED
Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CAPN9 binder may also engage these)

Protein	Name	Similarity
Q92178	—	1.000	Q92178 →
Q07009	—	1.000	Q07009 →
Q9D805	—	1.000	Q9D805 →
CAPN2	Calpain-2 catalytic subunit	1.000	landscape →
O08529	—	1.000	O08529 →
P00789	—	1.000	P00789 →
Q9GLG1	—	1.000	Q9GLG1 →
Q27971	—	1.000	Q27971 →
Q91VA3	—	1.000	Q91VA3 →
A6NHC0	—	1.000	A6NHC0 →
Q9GLG2	—	1.000	Q9GLG2 →
P97571	—	1.000	P97571 →
P35750	—	1.000	P35750 →
O35920	—	1.000	O35920 →
Q78EJ9	—	1.000	Q78EJ9 →
Q5NVS7	—	0.999	Q5NVS7 →
CAPN1	Calpain-1 catalytic subunit	0.999	landscape →
Q9TTH8	—	0.999	Q9TTH8 →
O35350	—	0.999	O35350 →
Q27970	—	0.999	Q27970 →
P20807	—	0.998	P20807 →
Q64691	—	0.998	Q64691 →
P16259	—	0.997	P16259 →
Q6J756	—	0.997	Q6J756 →
Q9GLG7	—	0.996	Q9GLG7 →
P43368	—	0.996	P43368 →
P06814	—	0.995	P06814 →
Q11002	—	0.995	Q11002 →
Q9UMQ6	—	0.994	Q9UMQ6 →
Q4V8Q1	—	0.994	Q4V8Q1 →