SCHEMBL19862148

SCHEMBL19862148

C1=Cc2ccc(-c3nc4ccccc4n3-c3ccccc3)cc2C2(c3ccccc31)c1ccccc1-c1cc3c(cc12)oc1ccccc13

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.34
ESR1 P03372 2/20 0.34
ESR2 Q92731 2/20 0.34
PTGER4 P35408 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
PRKACA P17612 1/20 0.32
RPS6KB1 P23443 1/20 0.32
GSK3B P49841 1/20 0.32
ROCK1 Q13464 1/20 0.32
GRIA1 P42261 1/20 0.32
CACNG8 Q8WXS5 1/20 0.32
CACNG2 Q9Y698 1/20 0.32
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
ALDH1A1 P00352 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19862135 0.97 ESR1 (0.35) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL18156779 0.92 RECQL (0.38) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL19862165 0.92 SIRT2 (0.34) ESR1ESR2PTGER4
SCHEMBL20224377 0.91 RECQL (0.38) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL19862215 0.89 SIRT2 (0.34) ESR1ESR2PTGER4ALDH1A1RXFP1
SCHEMBL20224430 0.89 RECQL (0.38) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL19869418 0.89 RECQL (0.38) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL19862253 0.86 RECQL (0.34) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL20224268 0.85 ESR1 (0.42) RECQLESR1ESR2PTGER4HDAC1
SCHEMBL19862109 0.85 RECQL (0.33) RECQLESR1ESR2PTGER4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10454039-B2 Compound and organic electronic device using the same SHANGHAI NICHEM FINE CHEMICAL CO., LTD. (CN) 2019-10-22 US disclosed
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-02-15 US disclosed
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME ORC3, AOX1, RCOR3 RECQL 150/4885ESR1 38/4885ESR2 47/4885
US-10454039-B2 Compound and organic electronic device using the same ORC3, AOX1, RCOR3 RECQL 150/4885ESR1 38/4885ESR2 47/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.