AOX1

Aldehyde oxidase · Q06278 · AOX1 on Sugi Atlas →

19,082 patent compounds predicted against AOX1, 15,471 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Perphenazine (SCHEMBL42125)	1.00	2/20
SCHEMBL356452	0.70	2/20
SCHEMBL172746	0.64	2/20
SCHEMBL259537	0.52	2/20
SCHEMBL514373	0.50	2/20
Erythromycin (SCHEMBL2601)	1.00	1/20
Erythromycin (SCHEMBL2602)	1.00	1/20
Amsacrine (SCHEMBL4047)	1.00	1/20
Ethinyl Estradiol (SCHEMBL4071)	1.00	1/20
Hydralazine (SCHEMBL7810)	1.00	1/20
Estradiol (SCHEMBL8049)	1.00	1/20
Quinacrine (SCHEMBL19225)	1.00	1/20
Quinacrine (SCHEMBL20205)	1.00	1/20
Menadione (SCHEMBL25970)	1.00	1/20
Zaleplon (SCHEMBL29118)	1.00	1/20
Pyridoxal (SCHEMBL29906)	1.00	1/20
Domperidone (SCHEMBL43729)	1.00	1/20
Isovanillin (SCHEMBL70256)	1.00	1/20
Ethinyl Estradiol (SCHEMBL73884)	1.00	1/20
Estradiol (SCHEMBL94610)	1.00	1/20

Clinical trials — most relevant to AOX1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Black Seed Oil in ADHD	PHASE2	NOT_YET_RECRUITING
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.	PHASE1/PHASE2	COMPLETED
Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria	PHASE1/PHASE2	SUSPENDED
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial	PHASE1	UNKNOWN
Vitamin C in Cardiac Surgery Patients	PHASE1	COMPLETED
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta	PHASE1	COMPLETED
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM	PHASE1	WITHDRAWN
Exercise and NO in HFrEF	EARLY_PHASE1	COMPLETED
Feasibility Test of Folic Acid on Acute Kidney Injury	EARLY_PHASE1	NOT_YET_RECRUITING
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns	nan	COMPLETED
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood	nan	NOT_YET_RECRUITING
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion	nan	NOT_YET_RECRUITING
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China	nan	COMPLETED
Prevention of Chronic Lung Disease (CLD - Prevention Study)	nan	NOT_YET_RECRUITING
Study of Protein Translocation in Patients With Beta-Oxidation Disorders	nan	COMPLETED
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma	nan	COMPLETED
Ginkgo Biloba Extract for Schizophrenia	nan	COMPLETED
Consumption of Apple Juice in Hemodialysis Patients	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Mucomyst for Hepatitis C	nan	SUSPENDED
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Genetic DAO Deficiency and Lower Urinary Tract Symptoms	nan	COMPLETED
Effects of Plant Concentrate Blend on Oxidative Stress in Healthy Humans	nan	COMPLETED
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
Demonstration of Carbonyl Stress on Hair Follicles	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AOX1 binder may also engage these)

Protein	Name	Similarity
P48034	—	1.000	P48034 →
Q5FB27	—	1.000	Q5FB27 →
O54754	—	1.000	O54754 →
P80456	—	1.000	P80456 →
Q5QE79	—	1.000	Q5QE79 →
Q9Z0U5	—	1.000	Q9Z0U5 →
Q7G192	—	1.000	Q7G192 →
C4NYZ3	—	1.000	C4NYZ3 →
Q7G191	—	1.000	Q7G191 →
Q6AUV1	—	0.999	Q6AUV1 →
H9TB17	—	0.999	H9TB17 →
Q5QE78	—	0.998	Q5QE78 →
Q5SGK3	—	0.998	Q5SGK3 →
Q9MYW6	—	0.998	Q9MYW6 →
Q12553	—	0.998	Q12553 →
P47990	—	0.997	P47990 →
Q00519	—	0.997	Q00519 →
Q8GUQ8	—	0.997	Q8GUQ8 →
P08793	—	0.997	P08793 →
Q7G9P4	—	0.997	Q7G9P4 →
P10351	—	0.996	P10351 →
P22985	—	0.996	P22985 →
P80457	—	0.996	P80457 →
Q852M2	—	0.996	Q852M2 →
G3X982	—	0.996	G3X982 →
Q5QE80	—	0.996	Q5QE80 →
Q3TYQ9	—	0.995	Q3TYQ9 →
F4JLI5	—	0.995	F4JLI5 →
H9TB18	—	0.993	H9TB18 →
Q54FB7	—	0.993	Q54FB7 →