SCHEMBL19862266

SCHEMBL19862266

C1=Cc2ccc(-c3nc(-c4ccccc4)cc(-c4cccnc4)n3)cc2C2(c3ccccc31)c1ccccc1-c1c2ccc2sc3ccccc3c12

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.35
DHODH Q02127 1/20 0.34
CYP19A1 P11511 1/20 0.32
GBA1 P04062 1/20 0.32
SMN1; SMN2 Q16637 3/20 0.31
ALDH1A1 P00352 2/20 0.31
NPC1 O15118 2/20 0.31
HPGD P15428 2/20 0.31
POLB P06746 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
LMNA P02545 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
RAB9A P51151 1/20 0.30
GPR84 Q9NQS5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19862272 0.98 DHODH (0.35) PDK2DHODHCYP19A1GBA1SMN1; SMN2
SCHEMBL19862261 0.97 PDK2 (0.35) PDK2DHODHCYP19A1GBA1SMN1; SMN2
SCHEMBL19862270 0.96 PDK2 (0.33) PDK2DHODHCYP19A1SMN1; SMN2ALDH1A1
SCHEMBL19862260 0.95 DHODH (0.35) PDK2DHODHCYP19A1GBA1SMN1; SMN2
SCHEMBL19862265 0.95 DHODH (0.35) PDK2DHODHCYP19A1GBA1SMN1; SMN2
SCHEMBL19862264 0.94 PDK2 (0.32) PDK2DHODHGBA1SMN1; SMN2ALDH1A1
SCHEMBL19862262 0.93 PDK2 (0.35) PDK2DHODHCYP19A1GBA1SMN1; SMN2
SCHEMBL19862268 0.93 MEN1 (0.31) ALDH1A1HPGDPOLB
SCHEMBL19862269 0.93 PDK2 (0.33) PDK2DHODHCYP19A1SMN1; SMN2ALDH1A1
SCHEMBL19862263 0.91 MEN1 (0.32) ALDH1A1HPGDPOLBKDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10454039-B2 Compound and organic electronic device using the same SHANGHAI NICHEM FINE CHEMICAL CO., LTD. (CN) 2019-10-22 US disclosed
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-02-15 US disclosed
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME NICHEM FINE TECHNOLOGY CO., LTD. (TW) 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180047918-A1 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME ORC3, AOX1, RCOR3 PDK2 2964/4885DHODH 1612/4885CYP19A1 371/4885
US-10454039-B2 Compound and organic electronic device using the same ORC3, AOX1, RCOR3 PDK2 2964/4885DHODH 1612/4885CYP19A1 371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.