Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19862569 | 1.00 | HRH3 (0.48) | HRH3TDO2OXTRAVPR1AATM | |
| SCHEMBL20152055 | 1.00 | HRH3 (0.48) | HRH3TDO2OXTRAVPR1AATM | |
| SCHEMBL20147458 | 0.92 | HRH3 (0.56) | HRH3TDO2NAMPTLIPE | |
| SCHEMBL20147459 | 0.88 | SLC6A4 (0.45) | HRH3TDO2OXTRAVPR1A | |
| SCHEMBL20069366 | 0.84 | TDO2 (0.54) | HRH3TDO2OXTRAVPR1AATM | |
| SCHEMBL19865665 | 0.84 | TDO2 (0.54) | HRH3TDO2OXTRAVPR1AATM | |
| SCHEMBL19865633 | 0.84 | TDO2 (0.54) | HRH3TDO2OXTRAVPR1AATM | |
| SCHEMBL1929289 | 0.83 | HRH3 (0.48) | HRH3ATMATRACACBCNR1 | |
| SCHEMBL20147962 | 0.82 | TDO2 (0.61) | HRH3TDO2OXTRAVPR1ANAMPT | |
| SCHEMBL26400528 | 0.80 | HRH3 (0.46) | HRH3ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | HRH3 4261/4885TDO2 2314/4885OXTR 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.