Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.49 |
| ▸ | CTSD | P07339 | 4/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828909 | 0.89 | BACE1 (0.43) | BACE1CTSDAPP | |
| SCHEMBL1821336 | 0.86 | BACE1 (0.65) | BACE1CTSD | |
| SCHEMBL1828227 | 0.81 | BACE1 (0.40) | BACE1CTSDAPP | |
| SCHEMBL1826421 | 0.81 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL7960662 | 0.80 | BACE1 (0.44) | BACE1CTSDAPP | |
| SCHEMBL7958287 | 0.79 | BACE1 (0.42) | BACE1CTSDAPP | |
| SCHEMBL1823413 | 0.78 | BACE1 (0.45) | BACE1CTSDAPP | |
| SCHEMBL1832026 | 0.78 | BACE1 (0.45) | BACE1CTSD | |
| SCHEMBL7971683 | 0.78 | BACE1 (0.41) | BACE1CTSDAPP | |
| SCHEMBL1829335 | 0.77 | BACE1 (0.44) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |