Sugi Predict

Sugi Predict / Compounds / SCHEMBL19863411

SCHEMBL19863411

SCHEMBL19863411

COc1ccccc1CNC(=O)Cc1ccc(-c2ccc(N3CCOC[C@@H]3C)cc2C)cn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 3/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ ABL1 P00519 1/20 0.42
▸ TUBB4A P04350 1/20 0.42
▸ TUBB P07437 1/20 0.42
▸ LYN P07948 1/20 0.42
▸ TUBA3C P0DPH7 1/20 0.42
▸ BCR P11274 1/20 0.42
▸ TUBA1B P68363 1/20 0.42
▸ TUBA4A P68366 1/20 0.42
▸ TUBB4B P68371 1/20 0.42
▸ TUBB3 Q13509 1/20 0.42
▸ TUBB2A Q13885 1/20 0.42
▸ TUBB8 Q3ZCM7 1/20 0.42
▸ TUBA3E Q6PEY2 1/20 0.42
▸ TUBA1A Q71U36 1/20 0.42
▸ TUBA1C Q9BQE3 1/20 0.42
▸ TUBB6 Q9BUF5 1/20 0.42
▸ TUBB2B Q9BVA1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19863401 0.89 SRC (0.48) SRCKMT2AABL1TUBB4ATUBB
SCHEMBL19863412 0.88 SRC (0.47) SRCABL1TUBB4ATUBBLYN
SCHEMBL23600320 0.88 SRC (0.55) SRCMEN1KMT2AABL1TUBB4A
SCHEMBL19863386 0.88 TUBB4A (0.53) SRCABL1TUBB4ATUBBLYN
SCHEMBL19863387 0.88 TUBB4A (0.53) SRCABL1TUBB4ATUBBLYN
SCHEMBL19863404 0.87 SRC (0.43) SRCABL1TUBB4ATUBBLYN
SCHEMBL19863403 0.86 SRC (0.46) SRCMEN1KMT2AABL1TUBB4A
SCHEMBL19863410 0.86 TUBB4A (0.54) SRCABL1TUBB4ATUBBLYN
SCHEMBL19863406 0.85 SRC (0.53) SRCKMT2AABL1TUBB4ATUBB
SCHEMBL19863426 0.84 SRC (0.49) SRCMEN1KMT2AABL1TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210196724-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE ATHENEX, INC. 2021-07-01 — — US disclosed
US-10973828-B2 Biaryl compositions and methods for modulating a kinase cascade ATHENEX, INC. (US) 2021-04-13 — — US disclosed
US-20190125754-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE OAKTREE FUND ADMINISTRATION, LLC 2019-05-02 — — US disclosed
US-20180042934-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE OAKTREE FUND ADMINISTRATION, LLC 2018-02-15 — — US disclosed
US-20180042934-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE OAKTREE FUND ADMINISTRATION, LLC 2018-02-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180042934-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE PLK1, MAP3K2, TNK2 SRC 81/4885MEN1 4001/4885KMT2A 1941/4885
US-20190125754-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE PLK1, MAP3K2, TNK2 SRC 81/4885MEN1 4001/4885KMT2A 1941/4885
US-10973828-B2 Biaryl compositions and methods for modulating a kinase cascade PLK1, MAP3K2, TNK2 SRC 81/4885MEN1 4001/4885KMT2A 1941/4885
US-20210196724-A1 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE PLK1, MAP3K2, TNK2 SRC 81/4885MEN1 4001/4885KMT2A 1941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.