⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627992 | 0.93 | — | — | |
| SCHEMBL9133050 | 0.91 | — | — | |
| SCHEMBL28738546 | 0.82 | — | — | |
| SCHEMBL10861516 | 0.76 | — | — | |
| SCHEMBL9488078 | 0.76 | — | — | |
| SCHEMBL10935435 | 0.73 | — | — | |
| SCHEMBL13935331 | 0.73 | — | — | |
| SCHEMBL25143395 | 0.73 | L3MBTL1 (0.30) | — | |
| SCHEMBL6906954 | 0.73 | CYP1A2 (0.33) | — | |
| SCHEMBL3236204 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396512-B2 | CDK2/4/6 inhibitors | PFIZER INC. (US) | 2022-07-26 | — | — | US | disclosed |
| CN-114516954-A | Polyether polyol and polyurethane foam | 红宝丽集团股份有限公司 | 2022-05-20 | — | — | CN | disclosed |
| WO-2021073593-A1 | AMINOPYRIMIDINE COMPOUND AS CDK2/4/6 TRIPLE INHIBITOR | 南京明德新药研发有限公司 | 2021-04-22 | — | — | WO | disclosed |
| US-20200392142-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2020-12-17 | — | — | US | disclosed |
| US-10233188-B2 | CDK2/4/6 inhibitors | PFIZER INC. (US) | 2019-03-19 | — | — | US | disclosed |
| WO-2018033815-A1 | PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS | PFIZER INC. (US) | 2018-02-22 | — | — | WO | disclosed |
| US-20180044344-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2018-02-15 | — | — | US | disclosed |
| US-20180044344-A1 | CDK2/4/6 Inhibitors | PFIZER INC. (US) | 2018-02-15 | — | — | US | disclosed |