SCHEMBL19864587

SCHEMBL19864587

CN(C)C(=O)c1ccc2c(c1)CCC(=O)N2

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 6/20 0.53
SMYD3 Q9H7B4 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.49
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
NPC1 O15118 1/20 0.45
MAPK13 O15264 1/20 0.45
MAPK12 P53778 1/20 0.45
MAPK11 Q15759 1/20 0.45
MAPK14 Q16539 1/20 0.45
KIF11 P52732 1/20 0.44
ALOX15 P16050 1/20 0.44
HTT P42858 1/20 0.44
HSD17B10 Q99714 1/20 0.44
PDE3B Q13370 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3999947 0.88 CA9 (0.51) CRBNSMYD3L3MBTL1HDAC1HDAC8
SCHEMBL4498867 0.86 EPHX2 (0.52) CRBNSMYD3HDAC3
SCHEMBL11043961 0.83 SMYD3 (0.50) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL6776207 0.83 L3MBTL1 (0.62) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL20773056 0.82 CRBN (0.60) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL29995492 0.81 SMYD3 (0.59) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL939611 0.81 SMYD3 (0.59) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL7321162 0.80 CRBN (0.47) CRBNSMYD3L3MBTL1HDAC3HDAC4
Succinimide SCHEMBL9294241 0.80 SMYD3 (0.58) CRBNSMYD3L3MBTL1HDAC3HDAC4
SCHEMBL27599042 0.80 CRBN (0.54) CRBNSMYD3L3MBTL1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018030550-A1 HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-02-15 WO disclosed