Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12603839 | 0.89 | SMN1; SMN2 (0.61) | RAB9ASMN1; SMN2NPC1METAP2L3MBTL1 | |
| SCHEMBL803150 | 0.84 | RAB9A (0.69) | RAB9ASMN1; SMN2NPC1METAP2L3MBTL1 | |
| SCHEMBL21035108 | 0.83 | CNR2 (0.44) | RAB9ASMN1; SMN2NPC1L3MBTL1NFKB1 | |
| SCHEMBL28029869 | 0.81 | HRH3 (0.46) | CNR2GRM2CYP3A4KDM1AMAOB | |
| SCHEMBL12970151 | 0.81 | KDM1A (0.53) | RAB9ASMN1; SMN2NPC1MAPTTP53 | |
| SCHEMBL19862542 | 0.81 | SLC6A2 (0.42) | RAB9ASMN1; SMN2NPC1L3MBTL1NFKB1 | |
| SCHEMBL8233550 | 0.79 | CCR1 (0.56) | RAB9ASMN1; SMN2NPC1METAP2L3MBTL1 | |
| SCHEMBL10553759 | 0.79 | SMN1; SMN2 (0.58) | RAB9ASMN1; SMN2NPC1METAP2L3MBTL1 | |
| SCHEMBL10561342 | 0.79 | SMN1; SMN2 (0.63) | RAB9ASMN1; SMN2NPC1METAP2L3MBTL1 | |
| SCHEMBL1686033 | 0.79 | KDM1A (0.49) | RAB9ASMN1; SMN2METAP2L3MBTL1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | RAB9A 1310/4885SMN1; SMN2 2225/4885NPC1 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.