Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IL6 | P05231 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21364287 | 0.94 | SMN1; SMN2 (0.51) | SMN1; SMN2CHRM2KMT2AMEN1HRH4 | |
| SCHEMBL19865657 | 0.83 | CHRM2 (0.46) | SMN1; SMN2CHRM2KMT2AMEN1HRH4 | |
| SCHEMBL7996152 | 0.81 | CHRM2 (0.40) | SMN1; SMN2CHRM2KMT2AMEN1HRH4 | |
| SCHEMBL10483877 | 0.81 | MAOB (0.43) | SMN1; SMN2CHRM2CXCR4 | |
| SCHEMBL10483930 | 0.80 | MAOB (0.49) | SMN1; SMN2CHRM2KMT2AMEN1CYP1A2 | |
| SCHEMBL24468090 | 0.80 | PTK2 (0.41) | KMT2AMEN1L3MBTL1NPC1GLA | |
| SCHEMBL30841920 | 0.80 | PTK2 (0.41) | KMT2AMEN1L3MBTL1NPC1GLA | |
| SCHEMBL24501321 | 0.76 | NPC1 (0.46) | SMN1; SMN2KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL16269042 | 0.76 | ITGB2 (0.42) | KMT2AMEN1L3MBTL1LMNAKDM4E | |
| SCHEMBL18272522 | 0.74 | L3MBTL1 (0.44) | SMN1; SMN2KMT2AMEN1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | SMN1; SMN2 2225/4885CHRM2 1925/4885KMT2A 3580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.