Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29597546 | 0.86 | PIK3CA (0.57) | ALDH1A1MAPTHTTLMNAPIK3CA | |
| SCHEMBL22023334 | 0.86 | PIK3CA (0.57) | ALDH1A1MAPTHTTLMNAPIK3CA | |
| SCHEMBL16668734 | 0.81 | FGFR4 (0.45) | ARPIK3CAROCK2ROCK1CDC42BPB | |
| SCHEMBL22023340 | 0.80 | PIK3CA (0.42) | ARMAPTPIK3CA | |
| SCHEMBL22079818 | 0.80 | PIK3CA (0.41) | PIK3CA | |
| SCHEMBL29596603 | 0.80 | PIK3CA (0.41) | PIK3CA | |
| SCHEMBL29597799 | 0.80 | PIK3CA (0.42) | ARMAPTPIK3CA | |
| SCHEMBL29597907 | 0.78 | LRRK2 (0.38) | ARPIK3CAROCK2ROCK1CDC42BPB | |
| SCHEMBL22023291 | 0.78 | LRRK2 (0.38) | ARPIK3CAROCK2ROCK1CDC42BPB | |
| SCHEMBL22023223 | 0.76 | ALDH1A1 (0.51) | ARALDH1A1MAPTHTTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018028664-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | 江苏豪森药业集团有限公司 | 2018-02-15 | — | — | WO | disclosed |