Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20963070 | 1.00 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL20963078 | 1.00 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL13634926 | 0.80 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL19867145 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL25733592 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL24774805 | 0.76 | DAGLA (0.43) | — | |
| SCHEMBL351195 | 0.76 | DPP4 (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGDPP4 | |
| SCHEMBL14995124 | 0.75 | — | — | |
| SCHEMBL28625821 | 0.75 | DAGLA (0.47) | — | |
| SCHEMBL22959569 | 0.74 | SLC6A2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | ATHENEX, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2019-05-02 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3CA 188/4885PIK3CD 227/4885PIK3CB 120/4885 |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3CA 188/4885PIK3CD 227/4885PIK3CB 120/4885 |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | PLK1, MAP3K2, TNK2 | PIK3CA 188/4885PIK3CD 227/4885PIK3CB 120/4885 |
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3CA 188/4885PIK3CD 227/4885PIK3CB 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.