Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 12/20 | 0.60 |
| ▸ | AKT1 | P31749 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17211657 | 0.88 | CNKSR1 (0.60) | CNKSR1AKT1SMN1; SMN2ALDH1A1PTGER1 | |
| SCHEMBL17211653 | 0.87 | CNKSR1 (0.73) | CNKSR1AKT1SMN1; SMN2PTGER3 | |
| SCHEMBL17211718 | 0.85 | CNKSR1 (0.64) | CNKSR1AKT1SMN1; SMN2ALDH1A1PTGER1 | |
| SCHEMBL19867362 | 0.77 | CNKSR1 (0.47) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL17211652 | 0.76 | CNKSR1 (0.85) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL15811504 | 0.76 | CNKSR1 (0.81) | CNKSR1AKT1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15811518 | 0.75 | CNKSR1 (1.00) | CNKSR1AKT1MEN1KMT2AALDH1A1 | |
| SCHEMBL17211661 | 0.74 | CNKSR1 (0.63) | CNKSR1AKT1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL17200780 | 0.74 | CNKSR1 (0.76) | CNKSR1AKT1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20798600 | 0.74 | CNKSR1 (0.76) | CNKSR1AKT1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |