Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 10/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17211657 | 0.87 | CNKSR1 (0.60) | CNKSR1AKT1ALDH1A1 | |
| SCHEMBL17211718 | 0.84 | CNKSR1 (0.64) | CNKSR1AKT1ALDH1A1 | |
| SCHEMBL19867339 | 0.77 | CNKSR1 (0.60) | CNKSR1AKT1USP2GAAALDH1A1 | |
| SCHEMBL19867335 | 0.76 | CNKSR1 (0.43) | CNKSR1AKT1L3MBTL1ALDH1A1HTT | |
| SCHEMBL17211653 | 0.76 | CNKSR1 (0.73) | CNKSR1AKT1 | |
| SCHEMBL19867255 | 0.76 | CNKSR1 (0.41) | CNKSR1AKT1L3MBTL1KDM4EHPGD | |
| SCHEMBL15811504 | 0.74 | CNKSR1 (0.81) | CNKSR1AKT1ALDH1A1MEN1KMT2A | |
| SCHEMBL18160902 | 0.74 | CNKSR1 (0.57) | CNKSR1AKT1L3MBTL1KDM4EHPGD | |
| SCHEMBL18160904 | 0.73 | CNKSR1 (0.50) | CNKSR1AKT1L3MBTL1KDM4EHPGD | |
| SCHEMBL17211661 | 0.73 | CNKSR1 (0.63) | CNKSR1AKT1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |