Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA9 | Q16790 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066066 | 0.91 | DRD2 (0.34) | CA12CA1CA9DRD2PREP | |
| SCHEMBL5375380 | 0.87 | PREP (0.33) | CA12CA1CA9DRD2PREP | |
| SCHEMBL6199747 | 0.84 | ALOX5AP (0.31) | — | |
| SCHEMBL4328701 | 0.84 | — | — | |
| SCHEMBL15986131 | 0.81 | NR1H2 (0.30) | — | |
| SCHEMBL5368454 | 0.81 | NR1H2 (0.30) | — | |
| SCHEMBL9376105 | 0.79 | — | — | |
| SCHEMBL5364453 | 0.76 | KMT2A (0.36) | CA12CA1CA9DRD2 | |
| SCHEMBL7197682 | 0.75 | KDM4E (0.32) | CA12CA1CA9 | |
| SCHEMBL7200102 | 0.75 | KDM4E (0.32) | CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294737-A | Hydrolysis, cyclization, condensation | THE RESEARCH FOUNDATION STATE UNIVERSITY OF NEW YORK (US) | 1994-03-15 | — | — | US | claimed |
| EP-1796664-B1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-11-27 | — | — | EP | disclosed |
| EP-1907394-B1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-29 | — | — | EP | disclosed |
| CN-101072780-A | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2007-11-14 | — | — | CN | disclosed |
| CN-101060838-A | Novel tetracyclic heteroatom containing derivatives as modulators of steroid sex hormone receptors | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-24 | — | — | CN | disclosed |