Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987155 | 0.83 | FGFR4 (0.49) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL29972334 | 0.73 | PIK3CA (0.44) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL8644295 | 0.73 | PIK3CA (0.73) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL18069431 | 0.72 | PIK3CA (0.52) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL28139444 | 0.72 | FGFR4 (0.44) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL30568954 | 0.71 | PIK3CA (0.58) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL28018836 | 0.71 | PIK3CD (0.48) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL15637813 | 0.71 | PIK3CD (0.45) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL30117539 | 0.71 | PIK3CD (0.45) | PIK3CAPIK3CDTDO2FGFR4EGFR | |
| SCHEMBL3535171 | 0.70 | PIK3CA (0.61) | PIK3CAPIK3CDTDO2FGFR4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512245-A1 | PYRIDOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075371-A1 | PYRIDOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |