Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987157 | 0.83 | PIK3CA (0.48) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL28441429 | 0.75 | ERN1 (0.50) | SRCALDH1A1TSHRABL1ERN1 | |
| SCHEMBL8644295 | 0.74 | PIK3CA (0.73) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL30478662 | 0.73 | EGFR (0.46) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL3535171 | 0.71 | PIK3CA (0.61) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL28178788 | 0.71 | EGFR (0.67) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL14876792 | 0.70 | ALDH1A1 (0.65) | ALDH1A1TSHRERN1 | |
| SCHEMBL2011008 | 0.70 | EGFR (0.55) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL20687402 | 0.70 | PIK3CD (0.73) | FGFR4PIK3CAPIK3CDEGFRTDO2 | |
| SCHEMBL14840458 | 0.70 | ALDH1A1 (0.50) | MAPK14ALDH1A1TSHRIMPDH2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512245-A1 | PYRIDOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075371-A1 | PYRIDOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |