Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 14/20 | 0.76 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.76 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812130 | 0.87 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPTMLNR | |
| SCHEMBL12812145 | 0.87 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPTMLNR | |
| SCHEMBL1443821 | 0.87 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPTMLNR | |
| SCHEMBL1443968 | 0.84 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MLNRNR1I2 | |
| SCHEMBL2339426 | 0.81 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MLNRNR1I2 | |
| SCHEMBL1784375 | 0.81 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPT | |
| SCHEMBL2332073 | 0.78 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPT | |
| SCHEMBL12812582 | 0.76 | KCNN4 (0.94) | KCNN4KCNE1KCNQ1MAPT | |
| SCHEMBL2337394 | 0.75 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPT | |
| Senicapoc SCHEMBL1443805 | 0.75 | KCNN4 (1.00) | KCNN4KCNE1KCNQ1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179115-B2 | Methods for treating malaria using potassium channel inhibitors | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-01-15 | — | — | US | disclosed |
| US-20180042872-A1 | METHODS FOR TREATING MALARIA USING POTASSIUM CHANNEL INHIBITORS | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042872-A1 | METHODS FOR TREATING MALARIA USING POTASSIUM CHANNEL INHIBITORS | KCNN1, KCNN2, KCNN3 | KCNN4 10/4885KCNE1 41/4885KCNQ1 5/4885 |
| US-10179115-B2 | Methods for treating malaria using potassium channel inhibitors | KCNN1, KCNN2, KCNN3 | KCNN4 10/4885KCNE1 41/4885KCNQ1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.