Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873623 | 1.00 | LPAR1 (0.44) | LPAR1LPAR3ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL19873621 | 0.93 | TACR1 (0.38) | LPAR1LPAR3AKR1C3AKR1C2ADRB3 | |
| SCHEMBL19873619 | 0.93 | TACR1 (0.38) | LPAR1LPAR3AKR1C3AKR1C2ADRB3 | |
| SCHEMBL19873564 | 0.92 | LPAR1 (0.36) | LPAR1LPAR3AKR1C3AKR1C2NAAA | |
| SCHEMBL19873567 | 0.92 | LPAR1 (0.36) | LPAR1LPAR3AKR1C3AKR1C2NAAA | |
| SCHEMBL19873658 | 0.91 | LPAR1 (0.36) | LPAR1LPAR3ALDH1A1ADRB1ADRB3 | |
| SCHEMBL19873656 | 0.91 | LPAR1 (0.36) | LPAR1LPAR3ALDH1A1ADRB1ADRB3 | |
| SCHEMBL19873569 | 0.91 | LPAR1 (0.43) | LPAR1LPAR3ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL19873568 | 0.91 | LPAR1 (0.43) | LPAR1LPAR3ALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL19873643 | 0.90 | LPAR1 (0.41) | LPAR1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |