Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873658 | 1.00 | LPAR1 (0.36) | LPAR1LPAR3EGFRNPC1RAB9A | |
| SCHEMBL19873647 | 0.93 | LPAR1 (0.37) | LPAR1LPAR3EGFRCHRM3CASR | |
| SCHEMBL19873644 | 0.93 | LPAR1 (0.37) | LPAR1LPAR3EGFRCHRM3CASR | |
| SCHEMBL19873564 | 0.91 | LPAR1 (0.36) | LPAR1LPAR3SMN1; SMN2CHRM3APP | |
| SCHEMBL19873567 | 0.91 | LPAR1 (0.36) | LPAR1LPAR3SMN1; SMN2CHRM3APP | |
| SCHEMBL19873623 | 0.91 | LPAR1 (0.44) | LPAR1LPAR3ALDH1A1APPLMNA | |
| SCHEMBL19873620 | 0.91 | LPAR1 (0.44) | LPAR1LPAR3ALDH1A1APPLMNA | |
| SCHEMBL19873547 | 0.90 | LPAR1 (0.40) | LPAR1LPAR3EGFRNPC1CHRM3 | |
| SCHEMBL19873548 | 0.90 | LPAR1 (0.40) | LPAR1LPAR3EGFRNPC1CHRM3 | |
| SCHEMBL19873599 | 0.90 | APP (0.39) | LPAR1LPAR3CHRM3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |