Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873638 | 1.00 | LPAR1 (0.37) | LPAR1LPAR3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19873554 | 0.92 | CHRNB2 (0.43) | LPAR1LPAR3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19873551 | 0.92 | CHRNB2 (0.43) | LPAR1LPAR3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19873633 | 0.90 | LPAR1 (0.44) | LPAR1LPAR3ENPP2CHRM3LPAR2 | |
| SCHEMBL19873632 | 0.90 | LPAR1 (0.44) | LPAR1LPAR3ENPP2CHRM3LPAR2 | |
| SCHEMBL19873596 | 0.90 | LPAR1 (0.34) | LPAR1LPAR3CHRM3 | |
| SCHEMBL19873594 | 0.90 | LPAR1 (0.34) | LPAR1LPAR3CHRM3 | |
| SCHEMBL19873543 | 0.90 | LPAR1 (0.38) | LPAR1LPAR3DGAT1NPC1RAB9A | |
| SCHEMBL19873545 | 0.90 | LPAR1 (0.38) | LPAR1LPAR3DGAT1NPC1RAB9A | |
| SCHEMBL19873550 | 0.89 | LPAR1 (0.34) | LPAR1LPAR3ENPP2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |