Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SNCA | P37840 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19877311 | 1.00 | TP53 (0.63) | TP53POLBSNCANPSR1RXFP1 | |
| SCHEMBL1607327 | 0.79 | KDM4E (0.68) | TP53POLBMIFMAPTGAA | |
| SCHEMBL4819273 | 0.77 | TP53 (1.00) | TP53POLBNPSR1MIFMAPT | |
| SCHEMBL4818246 | 0.77 | TP53 (0.64) | TP53POLBNPSR1RXFP1MIF | |
| SCHEMBL15572602 | 0.76 | HSD17B3 (0.54) | TP53POLBNPSR1RXFP1MIF | |
| SCHEMBL15572603 | 0.76 | HSD17B3 (0.54) | TP53POLBNPSR1RXFP1MIF | |
| SCHEMBL10706447 | 0.76 | TP53 (0.62) | TP53POLBNPSR1MIFMAPT | |
| SCHEMBL9716101 | 0.75 | MIF (0.59) | TP53POLBNPSR1RXFP1MIF | |
| SCHEMBL29601296 | 0.75 | MIF (0.59) | TP53POLBNPSR1RXFP1MIF | |
| SCHEMBL4818250 | 0.74 | TP53 (0.67) | TP53POLBNPSR1MIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500858-B1 | ASSAY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2023-12-27 | — | — | EP | disclosed |
| US-11415579-B2 | Assay for measuring a rate of reaction between a target and a ligand candidate | IMPERIAL COLLEGE INNOVATIONS LTD. (GB) | 2022-08-16 | — | — | US | disclosed |
| US-20190293641-A1 | ASSAY | IMPERIAL COLLEGE INNOVATIONS, LTD. (GB) | 2019-09-26 | — | — | US | disclosed |
| EP-3500858-A2 | ASSAY | Imperial Innovations Limited (GB) | 2019-06-26 | — | — | EP | disclosed |
| WO-2018033753-A2 | ASSAY | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-02-22 | — | — | WO | disclosed |