Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29415792 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL20050261 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL29415772 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL29415787 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19224424 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL29415788 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19228553 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19224587 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL20904050 | 1.00 | RIPK1 (0.73) | RIPK1 | |
| SCHEMBL19224421 | 1.00 | RIPK1 (0.73) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099981-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2018-04-12 | — | — | US | disclosed |
| US-9896458-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2018-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099981-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | PIK3CA, PLK1, PIK3CB | RIPK1 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.