Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.77 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.77 |
| ▸ | KDR | P35968 | 7/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.73 |
| ▸ | RET | P07949 | 4/20 | 0.73 |
| ▸ | SRC | P12931 | 3/20 | 0.73 |
| ▸ | ABL1 | P00519 | 3/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.73 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.73 |
| ▸ | PLK4 | O00444 | 2/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | FYN | P06241 | 2/20 | 0.73 |
| ▸ | LYN | P07948 | 2/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.73 |
| ▸ | AXL | P30530 | 2/20 | 0.73 |
| ▸ | FRK | P42685 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19888739 | 0.95 | RAF1 (0.73) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL16628087 | 0.91 | KDR (0.83) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL19888747 | 0.91 | RAF1 (0.71) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL29649810 | 0.91 | RAF1 (0.71) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL21125212 | 0.91 | KDR (0.85) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL30104231 | 0.91 | RAF1 (0.69) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL19878582 | 0.91 | RAF1 (0.69) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL257980 | 0.89 | RAF1 (0.82) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL16628056 | 0.87 | KDR (0.83) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL15624828 | 0.87 | RAF1 (1.00) | RAF1EPHX2KDRMAPK14RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066370-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200325103-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-10-15 | — | — | US | disclosed |
| US-10519113-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-12-31 | — | — | US | disclosed |
| US-20190202789-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2019-07-04 | — | — | US | disclosed |
| WO-2018035346-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICHAN SCHOOL OF MEDICINE AT MOUNT SINAL (US) | 2018-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325103-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | MAP3K1, KSR1, MAP3K11 | RAF1 16/4885EPHX2 2634/4885KDR 706/4885 |
| US-10519113-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | MAP3K1, KSR1, MAP3K11 | RAF1 16/4885EPHX2 2634/4885KDR 706/4885 |
| US-11066370-B2 | Kinase inhibitor compounds, compositions, and methods of treating cancer | MAP3K1, KSR1, MAP3K11 | RAF1 16/4885EPHX2 2634/4885KDR 706/4885 |
| US-20190202789-A1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | MAP3K1, KSR1, MAP3K11 | RAF1 16/4885EPHX2 2634/4885KDR 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.