Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | ABL1 | P00519 | 4/20 | 0.64 |
| ▸ | RET | P07949 | 4/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.64 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.64 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | FYN | P06241 | 2/20 | 0.64 |
| ▸ | LYN | P07948 | 2/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.64 |
| ▸ | AXL | P30530 | 2/20 | 0.64 |
| ▸ | FRK | P42685 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19878582 | 1.00 | RAF1 (0.69) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21124513 | 0.96 | RAF1 (0.66) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21084300 | 0.93 | RAF1 (0.69) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL1660411 | 0.93 | RAF1 (0.80) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21125009 | 0.92 | BRAF (0.63) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21125213 | 0.91 | RAF1 (0.67) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21124504 | 0.91 | RAF1 (0.69) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL19888748 | 0.91 | RAF1 (0.77) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL21125214 | 0.90 | RAF1 (0.66) | RAF1EPHX2KDRABL1RET | |
| SCHEMBL29649810 | 0.90 | RAF1 (0.71) | RAF1EPHX2KDRABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250281607-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | TORAY INDUSTRIES, INC. (JP) | 2025-09-11 | — | — | US | disclosed |
| EP-3500257-B1 | KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024178274-A2 | METHODS OF DEGRADING RAF(RAF) PROTEIN IN CELLS USING MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1/2 (MEK1/2) PROTEIN DEGRADERS | INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) | 2024-08-29 | — | — | WO | disclosed |
| EP-4378478-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | Toray Industries, Inc. (JP) | 2024-06-05 | — | — | EP | disclosed |
| CN-117677398-A | Medicine for treating and/or preventing cancer | 东丽株式会社 | 2024-03-08 | — | — | CN | disclosed |
| WO-2023008462-A1 | MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER | 東レ株式会社 | 2023-02-02 | — | — | WO | disclosed |